NTRK1 and neoplasm: In NSCLC, numerous types of biomarkers predicting intrinsic and extrinsic resistance have been investigated, including gene-expression, peripheral blood mononuclear cells, tumor-infiltrating immune cells, extracellular vesicles, gut microbial signatures, integrated models incorporating TMB adjusted for tumor purity, activating mutations in receptor tyrosine kinase mutations, molecular smoking signature, and human leukocyte antigen status [59–61].