Flavonoids have been reported to induce G2/M arrest and thus induce apoptosis by regulating cell cycle-dependent and pro-apoptotic proteins, thus activating caspase 3, up-regulating Bax/Bcl-xL, caspase 3 activity, and cleaved poly ADP-ribose polymerase (PARP); and down-regulating pro-caspases (caspase-3, -6, -8 and -9) proteins, suggesting C. aurantium may be beneficial for the treatment of cancer [58–60]. Here, CASP3 is linked to cancer.