Overall, compared to ADHF patients with low SIRI, those with high SIRI were more likely to be male, older, have diabetes, and be in NYHA class IV; They also had higher levels of WBC, neutrophil count, monocyte count, PLT, ALT, AST, Cr, BUN, FPG, and NT-proBNP, and lower levels of lymphocyte count, Alb, TC, HDL-C, and LDL-C. The gene discussed is GPT; the disease is diabetes mellitus.