TP53 and hepatocellular carcinoma: Oroxylin A (5,7-dihydroxy-6-methoxyflavone), a natural flavone from Oroxylum and Scutellaria species, has been shown to induce apoptosis in HepG2 hepatocellular carcinoma cells by stabilizing p53 at the post-translational level through the downregulation of MDM2 and inhibition of its E3 ligase activity (Mu et al., 2009[145]).