MDM2 and cancer: Examples include: i) Nutlin-3: A potent MDM2 antagonist that inhibits the p53-MDM2 interaction, leading to the activation of p53 (Lerma Clavero et al., 2023[112]); ii) Epigallocatechin Gallate (EGCG): Disrupts p53-MDM2 binding, preventing p53 degradation and enhancing its accumulation in cells (Bahena Culhuac and Bello, 2024[11]); iii) Leucomalachite Green (LMG): Inhibits the binding of p53 to MDM2, reactivating p53 in cancer cells (Koo et al., 2022[105]).