Beyond its well-established role in cancer, p53 is also implicated in the pathogenesis of several diseases, including cardiovascular and infectious diseases, neurodegenerative and metabolic disorders, and autoimmune conditions (Takatori et al., 2014[215]; Siegl and Rudel, 2015[206]; Kung and Murphy, 2016[106]; Szybińska and Leśniak, 2017[214]; Aloni-Grinstein et al., 2018[2]; Maor-Nof et al., 2021[132]; Men et al., 2021[135]). Here, TP53 is linked to cancer.