The role of p53 in breast cancer progression is complex and multifaceted, with p53 interacting with other signaling pathways, including the Wnt/β-catenin and PI3K/Akt/mTOR pathways, to modulate breast cancer cell behavior (Reddy et al., 2020[185]; Shahcheraghi et al., 2020[194]). The gene discussed is TP53; the disease is breast carcinoma.