The analysis of positively and negatively correlated genes and the gene set enrichment analysis demonstrated that depending on the FER1L4 expression level, the crucial pathways involved in melanoma development; IL6/JAK/STAT3, IL2/STAT5, KRAS, MTOR or PTEN, were dysregulated (Tangella et al., 2021[63]; Almeida et al., 2019[1]; Yang et al., 2020[75]). This evidence concerns the gene STAT3 and melanoma.