E2F1 and melanoma: Sehati et al., also showed that miR-330 had a suppressor ability and inhibits metastatic features of melanoma cells through downregulation of CXCR4, VIM, MMP‐9, and MCAM (CD146), and induces apoptosis through downregulation of E2F1, AKT1, and upregulation of caspase 3 (Sehati et al., 2020[56]).