We found a significant interaction between irritability and group in the NS and TD (p = .033, ηp2 = .03), and the NS and NF1 models (p = .009, ηp2 = .06) showing a stronger association between irritability and social impairments in NS compared to TD and NF1 children. The gene discussed is NF1; the disease is neurofibromatosis type 1.