This was especially interesting given that the PI3K signaling plays an important role in leukemia pathogenesis with limited knowledge in drug resistance.(67,68) Although 13 up- and 12 down-regulated genes were enriched in the PI3K signaling, we focused on 7 top-ranked downregulated genes (e.g., ITGA2, COL6A1, cyclin D1, PKN1, PDGFRA, F2R, HSP90AB1), because SENCR behaved as an oncogenic lncRNA in TKI resistance. The gene discussed is PKN1; the disease is leukemia.