Further, these genes were either downregulated to the highest levels in cells with SENCR knockdown, or well-established resistant genes and/or annotated to have a role in sustaining cancer cell survival and proliferation (Figure S9).(36,69,70) qPCR on RNAs from independent samples confirmed that, compared with scrambled controls, ITGA2, COL6A1, cyclin D1, PKN1, F2R, PDGFRA, and HSP90AB1 are downregulated in imatinib- and nilotinib-resistant K562 clones with knockdown of LN892, PROX1-AS1 or SENCR (Figure 6C). The gene discussed is PKN1; the disease is cancer.