By analyzing a gene expression profile resulting from SENCR knockdown, we identified a downstream mediator, PI3K signaling, which represents a central regulatory node controlling cell proliferation and apoptosis, and plays a critical role in leukemia drug resistance.(77) The key genes (i.e., ITGA2, COL6A1, cyclin D1, PKN1, PDGFRA and F2R), which are changed the most and likely involved in the PI3K pathway, could be downstream targets of PROX1-AS1, SENCR or LN892, because knockdown of these lncRNAs impairs the aforementioned target expression. The gene discussed is F2R; the disease is leukemia.