MED12 and Miyoshi myopathy: Although DEGs in Mediator kinase-inhibited MM SCs overlapped to a greater extent with those in MED12-mutant G44N cells than they did with those in patient UFs (Fig. 4A vs 4C), they also showed more significant overlap with patient UFs than did MED12 G44N mutant cells (Fig. 4A vs 4E).