We observed that short term (4.5 hour) inhibitor treatment in MM SCs led to upregulation of genes enriched for “MYC Targets” as well as “TGF-β Signaling” and “ECM Organization” (Fig. 1D and E), while longer-term (3.5 day) treatment induced genes associated with “MYC Targets” and “E2F Targets” (Fig. 2D and E). This evidence concerns the gene TGFB1 and Miyoshi myopathy.