HG is associated with increased risk of preeclampsia62 and the PGR risk locus for HG (rs12790159) is in LD (r2=0.86, D’=−0.95) with the risk locus for PE (rs2508372).63 Associations between increased GDF15 levels at 30–34 weeks’ gestation and subsequent preterm preeclampsia have been noted previously,64 but to our knowledge, this is the first time a GDF15 variant has been linked with serious preeclampsia. This evidence concerns the gene GDF15 and preeclampsia.