NLRP3 and familial dilated cardiomyopathy: Cell state composition analysis showed expansion of proliferating cells in donor controls (consistent with prior studies showing decreased myeloid proliferation in genetic DCM) (19, 24, 25) and expansion of NLRP3+ pro-inflammatory macrophages (Mac4) and monocytes in ACM (Fig. 3, G and H), consistent with prior a report (26).