Injections of either BIBN or AP-5 alone (no AIP) in the SI-BF mice did not result in an increase of NREM, such that the sleep-wake amounts post-injection were comparable to the saline condition, demonstrating that the receptor blockers do not specifically promote sleep (Fig. 6c), but instead blocked the relay of pain stimulus that leads to wakefulness. This evidence concerns the gene DHCR7-DT and autoimmune pancreatitis.