Hematoxylin and eosin staining of lung tissue sections revealed areas of pulmonary consolidation that exhibited evidence of cellular infiltrate, edema, and alveolar hemorrhage, in both the K18-hACE2 and hACE2 mice infected with SARS-CoV-2 relative to C57BL/6J mice or mock vehicle control infections. This evidence concerns the gene KRT18 and infection.