Next, we assessed whether phenotypically inflammatory BMDMs (polarized by LPS+IFN-γ) from hACE2 mice exhibited a response to SARS-CoV-2 infection in vitro, using a multiplicity of infection of 1.0 of SARS-CoV-2 followed by differential RNA-seq transcriptomic profiling (Fig. 7F, G). The gene discussed is IFNG; the disease is infection.