GNRHR and early-onset autosomal dominant Alzheimer disease: These included the TGF-β signaling pathway (raw p=5.8×10−6), Alzheimer disease presenilin pathway (p=5.8×10−5), Gonadotropin-releasing hormone receptor pathway (p=4.8×10−5), and the Cadherin signaling pathway (p=4.8×10−3).