Annotated genes in the TGF-β signaling (TGF-β) pathway and Gonadotropin-releasing hormone receptor (GRHR) pathways are highly overlapped (Figure 2A), as are genes in the Cadherin signaling (CADH) and Alzheimer’s disease presenilin(ALZ) pathways (Figure 2B). Here, GNRHR is linked to early-onset autosomal dominant Alzheimer disease.