TGFB1 and early-onset autosomal dominant Alzheimer disease: Annotated genes in the TGF-β signaling (TGF-β) pathway and Gonadotropin-releasing hormone receptor (GRHR) pathways are highly overlapped (Figure 2A), as are genes in the Cadherin signaling (CADH) and Alzheimer’s disease presenilin(ALZ) pathways (Figure 2B).