COL18A1 and systemic sclerosis: We sought to address this issue by conducting a systematic review and meta-analysis of studies investigating a such candidate biomarker, endostatin, an endogenous glycoprotein exerting anti-angiogenic effects, in SSc patients and healthy controls.<h4>Methods</h4>A literature search was conducted in the electronic databases Web of Science, PubMed, and Scopus from inception to 27 May 2024.