In addition, fragments of C2 molecules, C5bC6/C7 complex, Factor B, von Willebrand factor (vWF) and thrombospondin-1 (TSP1) were observed in a patient with acute COVID-19 and 6 months after hospital discharge, which increases endothelial damage and inflammation in the individual’s blood vessels (9).These circulating cytokine levels, some hematologic abnormalities such as alterations in the coagulation cascade, and molecules involved in the innate and adaptive immune response have already been suggested as valuable diagnostic and prognostic biomarkers of COVID-19 (10–12). This evidence concerns the gene THBS1 and COVID-19.