During the acute illness there is an inflammatory response, characterized by high levels of cytokines and chemokines, such as tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6) and interleukin-8 (IL-8), was observed in patients with COVID-19, especially in patients with a severe disease, compared to individuals without severe respiratory disease (2). The gene discussed is TNF; the disease is COVID-19.