The ability of squalene to inhibit the infiltration of TAMs was further confirmed by immunohistochemical (IHC) staining of the tumor tissues from the control mice and squalene-treated mice, as evidenced by a substantial decrease in F4/80+ cells (Figure 4A) and CD206+ macrophages (Figure 4B) in the squalene-treated group. This evidence concerns the gene MRC1 and neoplasm.