SRGAP2 and colorectal carcinoma: Targeting SRGAP2 with the aim of increasing the sensitivity of CRC cells to chemotherapy may be one of the key strategies to be used as a future strategy to ameliorate chemotherapy resistance in CRC cells (78) In addition, it was found that: metformin could alleviate the problem of chemoresistance in CRC cells by inhibiting CI, while substantially enhancing the ability to kill tumors (79).