In mouse models of CRC, the interaction between zinc finger protein 746 and Parkin disrupts the dynamic balance between mitochondrial fission and fusion, and by inhibiting the expression of proteins such as MFN1, MFN2, and PGC1α, significantly suppresses mitochondrial activity, thereby promoting resistance of CRC cells to chemotherapy. The gene discussed is MFN2; the disease is colorectal carcinoma.