PRKN and colorectal carcinoma: Huang and colleagues found that the expression of ZNF746/PARIS, a substrate for the interaction between ZNF746 and Parkin, was significantly higher in CRC cells than in normal colorectal tissues, and that overexpression of ZNF746 inhibited the expression of proteins such as MFN1, MFN2, and PGC1α, which could disrupt the dynamic equilibrium between fusion and fission in the mitochondria and greatly reduce mitochondrial activity.