Literature indicates that α-tocopheryl succinate (α-TOS), a redox-silent analog of vitamin E, can inhibit the interaction of Bak’s BH3 domain with Bcl-2 and Bcl-xL, weakening their biological activity and increasing mitochondrial outer membrane permeability, leading to apoptosis in breast and colon cancer cells (202). The gene discussed is BCL2; the disease is colonic neoplasm.