Mice carrying the human APOE ε2 allele demonstrate prolonged progression-free survival (PFS) compared to APOE ε4 carriers, with the mechanism linked to diminished T-cell cytotoxicity against tumor cells (11).Building on mechanisms observed in other cancers, these results underscore the importance of investigating how APOE ε2 may drive tumor progression in LUAD. Here, APOE is linked to cancer.