The average overall out-of-sample variances explained by our models were 58.1% [95% confidence interval (95% CI): (42%, 70.1%)] for atrophy; 56.1% [95% CI (46.7%, 64.6%)] for hypometabolism; 55.4% [95% CI (44.3%, 64.9%)] for amyloid-β and 48.7% [95% CI (37%, 58.6%)] for tau. This evidence concerns the gene MAPT and Atrophy.