Topological proximity to the epicentres’ proxies through the structural and functional connectivity networks were moderately correlated for atrophy (Pearson’s r = 0.52, P < 3 × 10−17) and for amyloid-β (Pearson’s r = 0.43, P < 8 × 10−12) and tau loads (Pearson’s r = 0.54, P < 2 × 10−18); their correlation was not significant for hypometabolism (Pearson’s r = 0.09, P > 0.15) (Fig. 1C). Here, MAPT is linked to Atrophy.