In our study, six VASARI features were found to predict IDH mutation status: F4, enhancement quality (AUC: 0.904); F5, tumor-enhancing proportion (AUC: 0.73); F6, tumor–non-enhancing proportion (AUC: 0.91); F7, necrosis proportion (AUC: 0.84); F14, proportion of edema (AUC: 0.75); and F17, diffusion characteristics (AUC: 0.79). The gene discussed is IDH1; the disease is neoplasm.