PLK4 and breast cancer: For instance, a comprehensive analysis of PLK using databases like Oncomine, GEPIA, cBioPortal, and Kaplan-Meier plots revealed that PLK1 and PLK4 are potential targets for precision treatment in BC, while PLK2, PLK3, and PLK5 may serve as new prognostic biomarkers (Jiawei et al., 2022).