DENND1A and polycystic ovary syndrome: In addition, through experiments on CHO cells and PCOS zebrafish models, it was found that Nimbin analog N2 can alleviate high testosterone-induced oxidative stress, restore damaged follicle maturation, and change the expression of PCOS susceptibility genes tox3 and dennd1a,opening up new ideas for the treatment of PCOS (Sudhakaran et al., 2023), as summarized in Table 1.