Reduced neuronal swelling was observed in neuron-specific Swell1 knockout (NEX-cKO) mice, it can therefore be hypothesized that this swelling is dependent on SWELL1 channels (Chen et al., 2024), suggesting that SWELL1 plays an important role in cerebral ischemia-reperfusion injury. This evidence concerns the gene LRRC8A and Cerebral ischemia.