The dissimilarity between the extent of PURPL expression and CIN/aneuploidy features upon reversine, cytochalasin B, and ZM447439 could be due to differences in the dynamic progression of RPE-1 towards chromosomal instability or aneuploidy and the extent of CIN or aneuploidy induced by different agents. Here, PURPL is linked to cervical squamous intraepithelial neoplasia.