CCN4 and hepatocellular carcinoma: WISP1 plays a critical role in maintaining normal cellular functions, including cell growth, adhesion, migration, and formation of the extracellular matrix.5 Although the implications of WISP1 in tumorigenesis remain debated, prior research indicates its notably reduced expression in HCC.12 Our current study reaffirms that increasing WISP1 expression significantly reduces hepatoma cell proliferation, as observed both in laboratory settings and in living organisms.