It is found to be overexpressed in certain cancers, including oral squamous cell carcinoma and colorectal cancer, contributing to tumor growth.6,7 In contrast, WISP1 is under-expressed in other types of cancers, such as melanoma, lung, and breast cancer, leading to different growth behaviors in these tumors.9-11 In HCC, our research has indicated a reduction in WISP1 expression, implying its role in suppressing tumor proliferation.12 This evidence concerns the gene CCN4 and oral cavity squamous cell carcinoma.