In addition, LPShas also been shown to promote cancer proliferation and metastasisin various cancer types by enhancing glycolysis through the NF-kB/Snail/HK3signaling axis.12 These negatory attributesof LPS prompted us to develop endotoxin-free OMVs with the aim ofenhancing the biological vesicles’ translational prospect. Here, NFKB1 is linked to cancer.