PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Research has documented a stronger association between MASLD and lung cancer in women.27 The PNPLA3 I148M variant is recognized as a major inherited factor for MASLD, while PNPLA3 itself acts as an independent risk factor for hepatocellular carcinoma in individuals with MASH.28 At the other locus, LINC00964 and TATDN1 exhibited posterior probabilities of 0.54 and 0.45 in skeletal muscle and the terminal ileum of small intestines.