One gene (EPHA2) has not been previously reported in the MASLD GWAS, while three genes (MAU2, GATAD2A, and TM6SF2) have been shown to be implicated in MASLD.21,25 Interestingly, the conditional and combined analyses showed that the TWAS expression signal contributed to the importance of the previously identified MASLD gene. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.