Likewise, a second generation EphA2‐CAR incorporating a CD8a transmembrane, and CD137, and CD3z costimulatory domains virally transduced into memory‐like NK cells at 20%–30% CAR positivity could also significantly enhance NK cell activity against preclinical models of HNSCC.47 This evidence concerns the gene EPHA2 and head and neck squamous cell carcinoma.