Additionally, weight loss induces an upregulation in anti‐inflammatory and protective factors like IL‐10 and adiponectin, both implicated in cancer suppression, as well as reduction in the activity of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in patients with type 2 diabetes, a critical mediator of chronic inflammation.1, 280. This evidence concerns the gene IL10 and cancer.