M2 macrophages recruited to the TME perform an important role in tumor progression, through the production of compounds enhancing and modulating angiogenesis (VEGF, MMP, TNFα, IL‐8), cancer cell migration (HGF, TGFβ, PDGF), and invasiveness (VEGF, EGF).246, 247. The gene discussed is TNF; the disease is neoplasm.