Co‐culture of macrophages with CRC cells increases the abundance of M2‐type cells, and current studies indicate the involvement of the phosphatidylinositol 3' ‐kinase/Protein kinase B/mammalian target of rapamycin kinase (PI3K/AKT/mTOR) signaling pathway in this process via Epidermal Growth Factor (EGF) secretion by CRC cells.238, 245. The gene discussed is MTOR; the disease is colorectal carcinoma.