In further stages, they may enhance the formation of a pro‐inflammatory microenvironment, that at first may promote tumor development but mainly contributes to anti‐tumor immunity, which results in the production of chemokines typical for cells with a pro‐inflammatory profile, for example, IL‐1β, IL‐6, TNFα, and MCP‐1.243, 244. This evidence concerns the gene TNF and neoplasm.