Repression of CCAAT/enhancer‐binding protein‐alpha (C/EBPα) and Peroxisome proliferator‐activated receptor gamma (PPARγ) Inducible nitric oxide synthase expression, which is mediated by factors such as TGFβ and TNFα secreted by CRC cells, appears to be one of the potential mechanisms implicated in the process of adipocyte dedifferentiation. This evidence concerns the gene TNF and colorectal carcinoma.