MME and subependymoma: Within the ST CNS compartment, underlying molecular signatures including DNA methylation and transcriptome analysis define three major subgroups, designated as ST-subependymoma (ST-SE; 5-year overall survival – 100%), ST-EPN YAP1 (5-year overall survival – 100%), and ST-EPN RELA (5-year overall survival – 75–80%) [1, 24, 27, 28, 30].