The PRS prediction accuracies in individuals with APOE(ε3ε3) genotype were achieved in ADNI123 using AD summary statistics and PRS-CS (UKBB) approach (AUC = 0.64), and with ADRD GWAS and quickPRS (AUC = 0.65) in BioFINDER, which is not sufficient to prioritize high risk individuals for clinical trials or other type of research. The gene discussed is APOE; the disease is Alzheimer disease.