To assess the impact of the POSTN-NOTCH1 axis on SCLC tumor growth, we established a subcutaneous xenograft model in BALB/c-nu/nu mice by co-injecting SCLC cells (H128) and HSCs (LX-2), in a 1:3 ratio (Fig. 6A). The gene discussed is NOTCH1; the disease is small cell lung carcinoma.