When comparing the diagnostic capabilities of CSF PTX3, CSF LDH, and CSF TLC, CSF PTX3 demonstrated lower sensitivity, specificity, PPV, and NPV in discriminating bacterial meningitis from aseptic meningoencephalitis than CSF LDH and CSF TLC, but it performed better than plasma CRP. Alternatively, Thomsen et al. [25] reported that CSF PTX3 has a better ability to differentiate them than CSF TLC does. Here, CRP is linked to bacterial meningitis.