To identify TDP-43 RNA targets that may be altered by the presence of mHTTex1, we carried out TDP-43 eCLIP-seq79 on HD R6/2 and NT mouse cortex and striatum (n = 8; age = 3 months; four males, four females) (Supplementary Fig. 4a). The gene discussed is TARDBP; the disease is Huntington disease.