We next compared the HD R6/2 excluded exons to splicing alterations identified in mouse NSC34 neuronal cells with small interferring RNA (siRNA)-mediated depletion of TDP-43 (ref. 73) and from wild-type mice treated with intracerebroventricular (ICV) injection of TDP-43 antisense oligo (ASO) or control (n = 4–5 per treatment). Here, TARDBP is linked to Huntington disease.