As there can be drastic differences in small molecule retention and behavior in mammalian cell lines, two diverse cell lines, A549 lung adenocarcinoma cells made to overexpress ACE2 and TMPRSS2, and Huh7 hepatocellular carcinoma cells overexpressing ACE2, were employed for these assays. The gene discussed is TMPRSS2; the disease is lung adenocarcinoma.