In humans, mutations in the FOXP3 gene lead to X-linked autoimmune lymphoproliferative disorder called IPEX (Immune dysregulation Polyendocrinopathy Enteropathy X-linked) syndrome, which includes insulin-dependent diabetes (Bennett and Ochs 2001). This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.