Our most recent study showed that UBE2F knockdown inhibited growth and survival of pancreatic cancer cells in vitro, and suppressed pancreatic tumorigenesis induced by KrasG12D in vivo via inducing accumulation of DIRAS2, a RAS inhibitor (Kontani et al, 2002) to block the MAPK/c-Myc signals (Chang et al, 2024). Here, DIRAS2 is linked to familial pancreatic carcinoma.