Our previous study showed that UBE2F, one of two known neddylation E2 conjugating enzymes, is overexpressed in non-small cell lung carcinomas and protects lung cancer cells from apoptosis by activating CRL5 (cullin-RING ligase-5) to promote ubiquitylation and degradation of proapoptotic protein NOXA (Zhou et al, 2017). Here, PROS1 is linked to lung cancer.