The role of CDK1 in haematopoiesis and leukemogenesis has been increasingly recognized, particularly because the phosphorylation of CDK1 at both its N- and C-termini can have profound effects on these processes (Fried and Friedman 2005), and CDK1 plays an important role in the treatment response of AML (Hedblom et al. 2013; Biggs et al. 2006). Here, CDK1 is linked to acute myeloid leukemia.