In contrast, dominantly-inherited, heterozygous missense mutations in RIPK1 generate a protein which resists caspase cleavage, promoting its ongoing activation and leading to recurrent fevers and lymphadenopathy – a condition known as cleavage-resistant RIPK1-Induced autoinflammatory disease (CRIA) [2]. This evidence concerns the gene RIPK1 and Lymphadenopathy.