Finally, SMYD3 mRNA or SMYD3 protein levels were not found to be significantly associated with survival in HPV-negative HNSCC patients; this may be due to the lower number of patients in the examined cohorts, as well as the fact that SMYD3 may be more important in the initial stages of HNSCC carcinogenesis. The gene discussed is SMYD3; the disease is head and neck squamous cell carcinoma.