More recently, Zeng et al.19 demonstrated that SMYD3 binds to and represses the tumor suppressor epithelial membrane protein 1 (EMP1) through H4K20me3 in gastric cancer cells, and that SMYD3 depletion significantly decreases the proliferation of gastric cancer cells in vitro and in vivo. The gene discussed is EMP1; the disease is gastric cancer.