SMYD3 and head and neck squamous cell carcinoma: Furthermore, utilizing the HPV-negative HNSCC cohorts of the TCGA and CPTAC databases, we found that SMYD3 mRNA or protein expression levels correlated positively with select cell cycle and EMT-related genes that we identified as direct downstream targets of SMYD3, which further validates their importance as SMYD3-mediated regulators of the cell cycle and EMT phenotypes in HPV-negative HNSCC (Fig. 5B, C, Supplementary Fig. 9).