Specifically, Sarris et al.3 reported that Smyd3 is necessary for the development of chemically induced liver and colon carcinomas in mice, and that it binds to and activates the transcription of oncogenes through H3K4me3, including EMT genes Snail1, Twist, Zeb1, Fn1 and Vimentin, and cell cycle genes CcnD1 and CcnE1. Aside from its role as an epigenetic regulator, and according to multiple reports showing that protein lysine methyltransferases may have both histone as well as non-histone substrates7, a number of cytoplasmic substrates of SMYD3 have been reported. The gene discussed is SMYD3; the disease is colon carcinoma.