ERLIN2 and hereditary spastic paraplegia: Other recent studies detected compound heterozygous ERLIN2 variants in pure HSP patients: c.108A>T + c.395C>T in a 17-year-old patient with normal MRI findings and spasticity onset at age 316 and c.481C>A + c.866T>C in a 67-year-old patient with onset at age 10 and normal MRI results17.