Previous research has reported that high levels of IL-6 are associated with promoting tumorigenesis, invasiveness, and metastasis in various types of cancer, such as gastric cancer, pancreatic cancer, colorectal cancer, lung cancer, and bile duct cancer44,62, with its substantial involvement in driving tumor progression via the IL-6/JAK/STAT pathway. This evidence concerns the gene IL6 and familial pancreatic carcinoma.