Moreover, compared to the mice of UAC group, the mice of CIS + UAC group had higher levels of pain-related substances including netrin-1 and PGE2 in the subchondral bone, whereas the mice of 6-OHDA + UAC and SCG + UAC groups had lower levels of netrin-1 (Fig. 4a) and PGE2 (Fig. 4b) in their subchondral bone. The gene discussed is NTN1; the disease is in situ carcinoma.