METTL3 and inflammatory bowel disease: Notably, a recent study has demonstrated that METTL3 is significantly upregulated in IBD samples, and Mettl3 downregulation attenuates LPS-induced cellular inflammation in mouse IECs in vitro and DSS-induced IBD in vivo through transfecting lentivirus containing specific shRNA for Mettl3 (Yang et al., 2022).