In model 1, which served as the base model, we adjusted for established clinical risk factors (age, sex, T1DM duration, and eGFR) and found that eight proteins (A2M, AMBP, APOB, APOC1, APOC2, APOC3, ITIH4, and RBP4) were significantly associated with incident CVD (model 1, Table 4). This evidence concerns the gene ITIH4 and type 1 diabetes mellitus.