In contrast, when we adjusted the base model for lipid risk factors (HDL-C, LDL-C, and log-transformed TG levels), the associations with T1DM status for five proteins, APOB, APOC2, APOC3, apolipoprotein C-IV, and RBP4, lost significance (model 4, Table 2), strongly suggesting that, for those five proteins, the lower levels of plasma LDL-C and TGs and/or higher HDL-C levels (Table 1) were the primary drivers of the associations with T1DM. The gene discussed is APOC3; the disease is type 1 diabetes mellitus.