In model 1, which served as the base model, we adjusted for established clinical risk factors (age, sex, T1DM duration, and eGFR) and found that eight proteins (A2M, AMBP, APOB, APOC1, APOC2, APOC3, ITIH4, and RBP4) were significantly associated with incident CVD (model 1, Table 4). The gene discussed is A2M; the disease is type 1 diabetes mellitus.