As the studies showed that the factors were low CD4 count, TB Preventive Therapy, risky behaviors [8, 9, 13–15], Poor nutritional status, not taking Co-trimoxazole Preventive Therapy (CPT), male sex, being female sex worker, functional status (being bedridden and ambulatory) [7, 8], early initiation of Anti-Retroviral Therapy (ART) for TB patients [7, 16], extra-pulmonary tuberculosis, residence, poor adherence, non-disclosure, treatment failure, Multi-Drug Resistance (MDR) TB, opportunistic infection, and WHO stages (stage I, II, III) [7, 13]. The gene discussed is CD4; the disease is Opportunistic infection.