NLRP3 and Guillain-Barre syndrome: Previousstudies using knockouts of NLRP3 have demonstrated that IL-1βresponses to GBS are primarily driven by the NLRP3-inflammasome ratherthan noncanonical inflammasomes or receptors, suggesting that off-targeteffects are unlikely.31 Furthermore, inthe assays used in this study, very little nonspecific activity hasbeen observed, suggesting that off-target effects are unlikely.65 That being said, future studies using mousemodels and genetic knockouts may be necessary to confirm these results.