However, there is no strong scientific evidence that supports pharmacological treatment to reduce AAA growth in humans [32,33]; the benefit of pharmacologic therapies, such as statins [34], antihypertensive drugs (beta blockers and angiotensin-converting enzyme inhibitors) [35,36], metformin [37], and antibiotics (roxithromycin and doxycycline) [38,39] in preventing rupture in small AAAs is controversial. This evidence concerns the gene ACE and achalasia-alacrima syndrome.