Cinacalcet treatment at ZT2 (Cina1) resulted in a 55.1% decrease in PTH and treatment at ZT14 (Cina2) resulted in a 29.0% decrease in PTH compared to the respective untreated CKD control group measured at the same time point which was 24 h since last administration of Cinacalcet. The gene discussed is PTH; the disease is chronic kidney disease.