This is very interesting in the light of our recent publication, which found in transgenic mice, that parathyroid glands with marked downregulation of the Oxidative phosphorylation/Electron transport chain and TCA cycle pathways had an insufficient compensatory PTH response to uremia leading to hypocalcemia and marked increase in Ki-67+ and PCNA+ cells [5]. The gene discussed is PCNA; the disease is Hypocalcemia.